Easy-graft : Crystal


Easy-graft: Crystal Overview

Histological analysis

Two months after filling of an 8 mm drill defect in a sheep humerus with biphasic calcium phosphate granulate (BCP). After the toluidine blue staining, bone appears blue. Bone has grown through the entire supercritical defect confirming the good osteoconductivity of the material. The violet staining of the granulate suggests that bone penetrated into the granules. The osteointegrated hydroxyapatite remains in the bone resulting in long-lasting volume preservation. The intimate contact between BCP and bone indicates an excellent biocompatibility of the material.

The high osteoconduction and the long-term stability makes easy-graft™CRYSTAL especially suitable for:

  • Large bone defects
  • Regions that are prone to bone atrophy
  • Patients with reduced bone regeneration potential

The Possible Uses are:

  • Cystectomy
  • Socket preservation
  • Sinus floor elevation
  • Bone spreading
  • Guided bone regeneration (GBR)
  • Periodontal defects
  • Periimplantitis

The innovative concept

  • High porosity due to bionic structure of granules
  • Injectable putty due to fast resorbing polylactic acid coating
  • Completely soluble
  • Initial antibacterial properties
  • Prevention of bacterial ingrowth due to coating
  • No loss of granules due to solid body formation in situ
  • High biocompatibility demonstrated in histological sections
  • Direct bone contact promotes tissue ingrowth
  • Blood uptake and tissue ingrowth due to porosity between granules
  • Bone formation in parallel to partial degradation of bone graft substitute

The advantages of easy-graft™CRYSTAL are:

  • Time & cost savings due to simple handling and shortend surgical procedure: - injectable - easy modelling in the pocket - In-situ hardening - In most cases no membrane needed
  • accelerated osteoconduction
  • long-term volume preservation
  • 100 % synthetic (60 % HA / 40 % ß-TCP)

Product Features

High osteoconduction and long-term volume preservation

easy-graft™CRYSTAL achieves an accelerated osteoconductivity thanks to its high micro- and macroporosity as well as its optimally balanced material formulation. The ß-TCP (40 %) resorbs slowly while the hydroxyapatit (60 %) remains in the defect and functions as a highly porous scaffold ensuring long-term volume preservation.
Detail of an easygraft ™CRYSTAL granule (electron-microscopic image)(SHOWN IN THE RIGHT)    >>
Cross section through an easy-graft™CRYSTAL granule (schematic representation)
Phase I
after application into the defect
Phase II
after degradation of the polylactide coating
Phase III
proceeding bone formation
Phase IV
the ß-TCP part has been degraded, HA is embedded in bone

How-to Use:mix-apply

easy-graft™ consists of a new unique biomaterial: bioceramic granules with a sticky surface. Apply directly into the defect, the bone graft will harden in situ within minutes...

Step by step...


Add BioLinker


Granules must be moistened (ca. 20-30s)


Discard excess fluid


Apply directly from the syringe


Condense well


Easy-graft Products

Reference Number C15-012 C15-013 C15-072 C15-073 C15-002 C15-003
Units 3 x 0.15 ml 6 x 0.15 ml 3 x 0.25 ml 6 x 0.25 m 3 x 0.4 ml 3 x 0.4 ml
Granule Size 450 - 630 µm 450 - 630 µm 450 - 1'000 µm 450 - 1'000 µm 450 - 1'000 µm 450 - 1'000 µm
Material Biphasic calcium phosphate (60% HA / 40% beta-TCP)
Indication Large bone defects and patients with reduced bone regeneration potential, e.g. in cystectomy, socket preservation, sinus floor elevation, bone spreading, guided bone regeneration (GBR), periodontal defects, periimplantitis