GUIDOR easy-graft











In their forward thinking article (Periodontology 2000, Oct 2003), Professors Hämmerle & Jung stated:

..."to simplify clinical handling, new materials should comprise a matrix with optimal cell ingrowth capacities and good mechanical properties, providing space for tissue regeneration. No membrane and no specific procedures for mechanical fixation should be necessary...

...the use of synthetic materials would result in lower surgical risks and lower morbidity in augmentation procedures and would represent an important step forward in simplifying bone regeneration techniques."

With GUIDOR easy-graft and its stunning handling and technical features such forward thinking considerations become reality.


The GUIDOR easy-graft difference



1: GUIDOR easy-graft system contains a pre-filled syringe of polymer coated granules (coloured blue in the illustration and labeled B in the scanning SEM image in the 'Granule Porosity' section below) together with a separate ampoule of polymer activator (BioLinker, as shown by dots in images 1).

2: When added to the syringe, BioLinker softens the polymer coating creating a sticky surface. GUIDOR easy-graft granules stick together when compressed and shaped.

3: When in contact with body fluids (highlighted in pink) BioLinker is flushed out of the material.

4: GUIDOR easy-graft hardens in a matter of minutes, forming a stable porous scaffold of interconnected granules matched to the defect shape (see also 'Macroporosity' SEM image below).





Granule Prosity

Osteoconductive bone grafts must stabilize the site, support a clot and provide space for new bone formation.





BioLinker and PLGA resorption

The resorption process for BioLinker and PLGA polymer coating takes place in two stages:

Stage 1) BioLinker is extracted within hours

More than 90% of BioLinker is removed from the bone graft substitute within three hours (1) and excreted through the urine within 1–3 days (2). BioLinker contains NMP, a solvent widely used in pharmaceutical and medical devices such as dental membranes, subcutaneous drug-release systems etc.





Stage 2) The PLGA polymer coating is resorbed over a few weeks

In parallel to the healing and regeneration process, the PLGA coating and adhesive connection between the granules gradually weakens (three to six weeks in vitro). The resorption process of PLGA is controlled by a hydrolytic cleavage of the polymer chains. Upon complete degradation, lactic acid and glycolic acid are formed. Both metabolites are innocuous, and they are excreted in the form of carbon dioxide and water.

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